Chemotherapy-Induced Myopathy: The Dark Side of the Cachexia Sphere

Cancer cachexia is a debilitating multi-factorial wasting syndrome characterised by severe skeletal muscle and dysfunction (i.e., myopathy). In the oncology setting, arises from synergistic insults both cancer–host interactions chemotherapy-related toxicity. The majority of studies have surrounded interaction side cancer cachexia, often overlooking capability chemotherapy to induce cachectic myopathy. Accumulating evidence in experimental models suggests that some chemotherapeutic agents rapidly myopathy, although underlying mechanisms responsible vary between agents. Importantly, we highlight capacity specific as not all chemotherapies been evaluated for cachexia-inducing properties—alone or clinically compatible regimens. Furthermore, discuss surrounding therapeutic strategies chemotherapy-induced models, with particular focus on exercise interventions adjuvant candidates targeted at mitochondria.